At least they know this much: neither team is playing a stitch of defense. The Giants get the 3-point nod because they are at home. Not that that matters, since they are only 6-4 at the new stadium. Since MetLife opened last year, the Giants have won more games on the road (7) then they have at home.
The Bills are 3-0 at Orchard Park this year and 1-1 on the road. They are 4th in the league in rushing and aren't very careless with the football, sporting a league-best +11 turnover ratio. The Giants will have to earn this one.